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与肺癌患者抗瘤疗法相关的肺栓塞时间模式和危险因素
Yi-Wen Zhang1, Dong-Chun Ma2, Rui Tao1
1Department of Respiratory Medicine, Anhui Medical University Clinical College of Chest &Anhui Chest Hospital, Hefei, 230022, People's Republic of China.
Annals of vascular surgery
|September 5, 2025
在PubMed 上查看摘要
概括
肺癌患者的肺栓塞 (PE) 风险随着治疗而变化. 外科手术增加了PE风险,特别是在治疗的早期,强调需要监测和个性化抗凝策略.
科学领域:
- 癌症学
- 心脏病学
- 肺部医学
背景情况:
- 肺癌患者面临肺栓塞的风险增加.
- 特定抗瘤疗法与肺癌PE发病之间的关联需要进一步描述.
- 识别高风险人群对于及时干预至关重要.
研究的目的:
- 研究各种抗瘤疗法与肺栓塞 (PE) 发病时间之间的关系.
- 在癌症治疗期间确定患PE风险较高的患者子组.
- 为肺癌PE的临床监测和管理策略提供信息.
主要方法:
- 在抗瘤治疗期间发生PE的106名肺癌患者的回顾性分析 (2019-2025年).
- 数据收集包括人口统计,癌症阶段,治疗类型和PE发病时间.
- 经过螺旋CT或肺血管扫描证实PE诊断.
主要成果:
- 在50.95%的病例中,PE发生在诊断后的六个月内.
- 与联合治疗 (15. 52个月) 相比,手术干预是PE的独立风险因素,较早发病 (1. 81个月).
- 在开始治疗后的三个月内,经过化疗 (46. 15%),向治疗 (34. 78%) 和手术 (77. 78%) 的治疗,发育前期的发病率有所不同.
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结论:
- 在肺癌中使用的抗瘤治疗类型显著影响了PE的发生率和时间.
- 在这一群体中,手术是PE发展的关键风险因素.
- 在整个肺癌治疗过程中,警监测,风险分层和量身定制的抗凝药是必不可少的.


