在瘤中,可转移元素的高表达与免疫透率的增加和免疫治疗后的结果的改善有关
Benjamin A Nacev1,2, Martina Bradic3, Hyung Jun Woo3
1Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA nacevba@upmc.edu.
Journal for immunotherapy of cancer
|September 5, 2025
概括
在接受免疫检查点抑制 (ICI) 治疗的肉瘤患者中,可移植元素 (TE) 和IKZF1表达预测了免疫透和更好的结果. 这些发现表明TEs和IKZF1是改善ICI疗效的潜在生物标志物和治疗点.
科学领域:
- 癌症学
- 免疫学
- 遗传学
背景情况:
- 在肉瘤中免疫检查点抑制 (ICI) 反应有限且多样化.
- 确定影响ICI结果的因素对于提高疗效和患者选择至关重要.
- 可转移元素 (TE) 是表观遗传沉默的,可以激活抗瘤免疫力.
研究的目的:
- 调查可转移元素 (TE) 表达是否影响瘤亚型中的ICI结果和免疫透.
- 确定表观遗传调节基因在预测肉瘤中免疫透的作用.
- 在接受ICI治疗的肉瘤患者中探索TE和IKZF1表达和临床结果之间的相关性.
主要方法:
- 分析了来自ICI试验的肉瘤活检 (n=67) 的转录组数据.
- 机器学习 (拉索惩罚后勤回归) 确定了免疫状态的预测因素.
- 在多个队列中评估了TE/ IKZF1表达,免疫透,通路和临床结果之间的相关性.
主要成果:
- 在瘤中,TE和表观基因调节器表达显著预测了增强的免疫状态.
- TE亚家族和IKZF1表达是关键预测因素,与免疫透和炎症途径具有正相关性.
- 增加TE和IKZF1表达与改善的临床结果有关,包括整体存活率和无进展存活率.
结论:
- TE和IKZF1表达是预测瘤免疫透和ICI治疗结果的有希望的生物标志物.
- 需要进一步的转化研究来探索TE和IKZF1作为治疗点.
- 这些发现可能有助于优化患者选择,并提高ICI在肉瘤治疗中的有效性.
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