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Updated: Sep 8, 2025

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
09:16

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

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细胞纤维素通过整合素α4β1介导的PAR1和SCD升高而加剧α-synuclein聚合

Zifeng Huang1, Hui Zhong1, Yingqiong Lu2

  • 1Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong 510280, PR China.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
|September 5, 2025
PubMed
概括

细胞纤维素 (cFn) 通过整合蛋白α4β1破坏线粒体并破坏脂质代谢,从而加剧帕金森病的病理. 针对cFn可能为PD提供一种新的治疗方法.

关键词:
纤维素线粒体功能障碍帕金森病聚 (ADP-ribose) (PAR) 聚合酶-1甲酸脱酶α-合成核素

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