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相关概念视频

Multipotency of Hematopoietic Stem Cells01:19

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Commitment is the  process whereby stem cells:
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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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相关实验视频

Updated: Sep 8, 2025

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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通过单细胞多组学解决白血病干细胞异质性和可塑性

Frank Y Huang1, Andreas Trumpp2, Patrick Stelmach2

  • 1Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM, gGmbH), Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.

Seminars in hematology
|September 5, 2025
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概括

白血病干细胞 (LSC) 驱动急性髓性白血病 (AML) 复发,并且非常多样化. 单细胞多组学有助于了解LSC异质性,以更好地诊断和治疗AML.

关键词:
急性骨髓性白血病 (AML)白血病干细胞 (LSC)可塑性治疗反应和耐药性维尼托克拉克斯

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科学领域:

  • 血液学
  • 癌症生物学
  • 基因组学

背景情况:

  • 急性髓性白血病 (AML) 是由多种白血病干细胞 (LSC) 驱动的.
  • 这种LSC异质性会影响治疗反应和疾病复发.
  • 了解LSC多样性对于有效的AML治疗至关重要.

研究的目的:

  • 审查AML中LSC异质性的原因和后果.
  • 突显单细胞多组学在解剖LSC多样性的进展.
  • 探索这些技术如何改善AML诊断和监测.

主要方法:

  • 对当前的科学文献进行回顾.
  • 专注于单细胞多组技术 (基因组学,转录组学,表观组学,蛋白质组学).
  • 在AML中分析LSC异质性和可塑性.

主要成果:

  • 这种异质性源于遗传和非遗传因素.
  • 单细胞多组学提供单个LSC的高分辨率分子快照.
  • 这项技术可以更深入地了解LSC的状态和脆弱性.

结论:

  • 在AML中,LSC的异质性带来了挑战,也带来了治疗机会.
  • 单细胞多组学正在改变AMLLLSC多样性的研究.
  • 这些技术的进步有望彻底改变AML诊断和患者监测.