与和多基物质 (PFAS) 暴露相关的抑郁结果
Humairat H Rahman1, Weston R Stokey2, Stuart H Munson-McGee3
1New Mexico State University, Las Cruces, NM, 88003, USA. hrahman@nmsu.edu.
Environmental science and pollution research international
|September 5, 2025
概括
暴露于某些和多基物质 (PFAS),如分支酸异构体,n-酸和酸,与美国成年人的抑郁风险增加有关. 需要进一步的研究来证实这些发现.
科学领域:
- 环境健康
- 毒理学
- 流行病学
背景情况:
- 被称为"永久化学品"的和多基物质 (PFAS) 是广泛使用和持久的环境污染物.
- PFAS在人体组织中生物累积,导致各种健康问题,包括与心理健康状况的潜在联系.
- 抑郁症是严重的公共卫生问题,
研究的目的:
- 在美国成年人中调查暴露于9种特定的PFAS亚型与抑郁症结果之间的关联.
- 确定哪些PFAS亚型,如果有的话,与抑郁症的患病率或严重程度增加相关.
- 在PFAS暴露的背景下分析与抑郁症相关的人口和生活方式因素.
主要方法:
- 利用2015-2018年国家健康和营养检查调查 (NHANES) 的数据,分析血清PFAS水平和抑郁症得分 (PHQ9).
- 使用多重线性回归和多重逻辑回归的统计模型来评估相关性.
- 控制潜在的混变量,包括人口和生活方式因素.
主要成果:
- 在中等度暴露于分支 perfluorooctanoic 酸 (BFOA),n- perfluorooctanoic 酸 (NFOA) 和 perfluorononanoic 酸 (PFNA) 和抑郁症发生之间发现了显著的正相关性.
- 暴露于这些特定的PFAS亚型的几率表明抑郁症的可能性增加.
- 与抑郁症常见的共同变量包括女性性别,非伴侣婚姻状况,肥胖和目前的吸烟.
结论:
- 特定的PFAS亚型,包括BFOA,NFOA和PFNA,在美国成年人中与抑郁症有潜在的毒性相关性.
- 这些发现凸显了对PFAS毒理学和心理健康影响的持续研究的需要.
- 公共卫生倡议应侧重于教育,测试和减少PFAS暴露的努力.
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