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结直肠癌存活率中的CRP-白蛋白-淋巴细胞 (CALLY) 指数的预后价值:多中心回顾性队列研究

Mansour Bahardoust^1,2, Mohammadsadra Shamohammadi³, Negin Danesh⁴

¹Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Journal of gastrointestinal cancer

|September 5, 2025

概括

C反应蛋白 (CRP) - 白蛋白 - 淋巴细胞 (CALLY) 指数是结肠直肠癌 (CRC) 的新生物标志物. 在CRC患者中,较高的CALLY指数与更好的生存率和降低的复发风险有关.

科学领域:

癌症学
生物标志物研究
临床预测

背景情况:

结肠直肠癌 (CRC) 是一个重大的全球健康挑战,死亡率很高,特别是在晚期.
现有的预后工具往往缺乏对全身炎症,营养状况和免疫功能的全面评估.

研究的目的:

在结直肠癌 (CRC) 患者中评估新型C反应蛋白 (CRP) - 白蛋白 - 淋巴细胞 (CALLY) 指数的预后值.
确定CALLY指数与整体存活率 (OS) 以及无复发存活率 (RFS) 之间的关联.

主要方法:

在2012年至2022年期间接受治疗的1447名CRC患者进行了回顾性多中心队列研究.
患者根据CALLY指数分为两组:≥2 (n=945) 和<2 (n=502).
人口,瘤和病理数据被提取并分析生存关联.

主要成果:

在CALLY指数≥2的患者中,5年生存率为80. 3%,而CALLY指数<2的患者则为64. 9% (P=0. 001).
多变量分析证实CALLY指数是OS的重要独立预测指标 (HR0.84,P=0.001).
其他几个因素包括年龄,BMI,瘤阶段,转移和辅助化疗也显著影响了生存率.

结论:

在结肠直肠癌患者中,CALLY指数是改善生存率和减少复发的重要独立预测指标.
较高的CALLY指数与更好的预后相关,表明其作为CRC预后标准的有用性.
通过整合炎症,营养和免疫, 这种多维生物标志物为患者的结果提供了宝贵的见解.

关键词:

卡利大肠直肠癌炎症发生营养成分复发情况生存情况

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