在社区人口中,内皮炎症标志物与大脑小血管疾病之间的关联
Zhang Xia1,2, Lingling Jiang1,2, Xueli Cai3
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
概括
血管细胞粘附分子1 (VCAM-1) 与大脑小血管疾病 (CSVD) 的存在和严重程度有关. 细胞间粘附分子1 (ICAM-1) 与CSVD没有关联,表明VCAM-1
科学领域:
- 神经科学
- 心血管科学
- 生物标志物
背景情况:
- 内皮炎在脑小血管疾病 (CSVD) 的发病过程中起着关键作用.
- 血管细胞粘附分子1 (VCAM-1) 和细胞间粘附分子1 (ICAM-1) 是已确定的生物标志物,表明内皮炎症.
研究的目的:
- 调查VCAM-1和ICAM-1水平与CSVD的存在和负担之间的关联.
- 评估这些生物标志物在CSVD和认知障碍中的预测价值.
主要方法:
- 一项涉及2596名社区居民的横截面研究.
- 在禁食静脉血液样本中测定VCAM-1和ICAM-1水平.
- 使用蒙特利尔认知评估 (MoCA) 评估认知功能,并通过3.0TMRI评估CSVD标志物 (白质高强度,缺口,微型血液,扩大周围血管空间).
主要成果:
- 升高的VCAM-1水平与CSVD存在的可能性增加 (OR=1.16) 和CSVD负担增加 (cOR=1.11-1.16).
- VCAM-1 证明了CSVD存在和认知障碍的CSVD的改善预测.
- ICAM-1水平与CSVD存在或负担没有显著的关联,也没有改善预测模型.
结论:
- 内皮炎症,特别是VCAM-1的升高,与大脑小血管疾病的存在和增加相关.
- VCAM-1 作为潜在的生物标志物用于识别患有CSVD的个体并评估疾病严重程度,而ICAM-1 在这种情况下似乎不是一个相关的标志物.
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