免疫受损患者中的登革热:系统性审查和分析
Juthaporn Cowan1, Viravarn Luvira2,3, Sivaporn Gatechompol4
1Division of Infectious Diseases, Department of Medicine, University of Ottawa, Ottawa, Canada.
Journal of travel medicine
|September 6, 2025
概括
登革热在免疫功能低下的人群中是严重的,通常是致命的,特别是在干细胞移植 (HSCT) 后. 这种病毒感染可能长期存在,对免疫力低下的旅行者构成风险.
科学领域:
- 传染性疾病
- 免疫学
- 公共卫生
背景情况:
- 全球登革热和免疫功能低下病例的发病率正在上升.
- 在免疫功能低下的人群中严重登革热的数据有限.
- 需要证据来指导免疫受损的旅行者.
研究的目的:
- 系统地审查和对免疫功能低下个体的登革热频率和结果进行元分析.
- 评估现有研究中的偏差风险.
- 提供临床管理和旅行建议.
主要方法:
- 对相关研究进行系统审查和元分析.
- 不包括非人类和评论文章.
- 使用ROBINS-E工具进行偏差风险评估.
主要成果:
- 包括85项研究,其中63项具有偏差的高风险.
- 登革热的发病率在各个群体中为0.3%至6.3%.
- 严重的登革热和死亡率显著,特别是在HSCT患者中 (66. 7%的死亡率).
- 在尿液中检测到长达2年的登革热RNA;在9个月时分离出活力病毒.
结论:
- 登革热对免疫功能低下的个体,特别是接受HSCT的人来说,具有很高的严重性和死亡风险.
- 长期存在的病毒是一个关键问题.
- 调查结果强调需要谨慎的旅行建议和管理策略.
相关概念视频
Immunodeficiency Diseases
1.2K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.2K
Factors Affecting the Risk of Infection
12.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.2K
Pulmonary Tuberculosis I
321
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
321
Development of Immunocompetence
444
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
444


