生疹疫苗与中风风险之间的关联:基于人口的嵌套病例对照研究
Amir Yahav1, Doaa Ryan1, Jonathan Naftali2
1Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
概括
带状疹疫苗 (ZVL) 显著降低了整体中风,缺血性中风和脑内出血 (ICH) 的风险. 这种保护作用在年轻男性中最强,并且随着时间的推移而减弱.
科学领域:
- 流行病学
- 疫苗学
- 神经学
背景情况:
- 关于带状疹疫苗对中风风险的影响,特别是脑内出血 (ICH) 的证据有限且不一致.
- 带状疹通常被称为带状疹,
- 了解疫苗诱导的大脑血管事件的保护对于公共健康至关重要.
研究的目的:
- 调查生疫苗 (ZVL) 与整体中风风险及其亚型之间的关联.
- 分析ZVL对中风的保护作用如何随着疫苗接种以来的时间变化.
- 通过年龄和性别探索ZVL中风的潜在变化.
主要方法:
- 基于人口的嵌套病例控制研究利用以色列最大的医疗保健提供者 (2015-2023) 的数据.
- 包括50岁以上的个体;中风病例与年龄,性别,行业和指数日期的对照相匹配.
- 由先前处方填充定义的ZVL暴露;计算了调整后的概率比率 (OR).
主要成果:
- ZVL与整体中风 (OR 0. 65),缺血性中风 (OR 0. 65) 和ICH (OR 0. 64) 的几率显著降低.
- 随着时间的推移,保护作用减弱:0. 56在2.5年内,0. 71 (2. 5-5年) 和0. 81 (> 5年).
- 在65岁以下的个体和男性中观察到更强的保护;相互作用P值<0.05.
结论:
- 佐斯特活疫苗 (ZVL) 显示出对缺血性中风和脑内出血 (ICH) 的保护性关联.
- 疫苗对中风的保护作用在接种疫苗后逐渐减少.
- 男性和年轻人 (65岁以下) 似乎从ZVL中获得更大的中风风险降低.
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