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Updated: Sep 8, 2025

A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1
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ssDNA和ssRNA促进SAMHD1的阶段凝结

Brandon E Smith1, Ankita Pohnerkar1, Benjamin Orris1

  • 1Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, United States.

Biochemistry
|September 6, 2025
PubMed
概括

通过GTP调节的核酸,SAMHD1蛋白凝结成类似液体的液滴. 这种液-液相分离 (LLPS) 对癌症和病毒感染疗法有影响.

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