运动干预对多发性硬化症患者焦虑症状的影响:系统性审查和元分析
Yvonne C Learmonth1, Megan R Hawkins2, Amalia Karahalios3
1Discipline of Exercise Science, Murdoch University, Perth, WA, Australia; Perron Institute for Neurological and Translational Science, Perth, WA, Australia; Personalised Medicine Centre, and Centre for Health Ageing, Healthy Futures Institute, Murdoch University, Perth, WA, Australia.
Multiple sclerosis and related disorders
|September 6, 2025
概括
在患有多发性硬化症 (MS) 患者中,运动对减轻焦虑症状有很小的积极影响. 这种可访问的干预措施为MS患者的焦虑管理提供了有希望的方法.
科学领域:
- 神经科学与康复
- 精神病学与心理健康
- 运动科学
背景情况:
- 在被诊断为多发性硬化症 (MS) 患者中,焦虑症状很普遍.
- 这种群体需要有效且易于获得的干预措施来控制焦虑.
研究的目的:
- 系统地评估运动干预对MS患者焦虑症状的影响.
- 确定影响减轻焦虑的运动有效性的特征.
- 在相关研究中评估干预设计的报告质量.
主要方法:
- 进行了随机对照性运动试验的系统审查和元分析.
- 在多个数据库 (MEDLINE,Embase,PsycINFO,CENTRAL,CINAHL,Scopus,Web of Science,PEDro) 进行了搜索,截至 2024 年 11 月.
- 使用随机效应模型分析了干预后焦虑症状的差异,用Cochrane风险偏差2. 0评估偏差风险.
主要成果:
- 在MS患者中,运动对减轻焦虑症状产生了微小而具有统计意义的积极影响 (SMD: 0.26).
- 在包括的18个随机对照试验中观察到适度的异质性.
- 由于依赖于自我报告的措施和未蒙蔽的参与者,所有试验都存在偏差的高风险;对干预设计元素的报告有限.
结论:
- 运动在缓解多发性硬化症患者的焦虑症状方面具有有益作用.
- 运动是一种安全的,容易获得的,
- 未来的研究应优先考虑可靠的试验设计,预先注册和干预组件的详细报告.
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