脊椎动脉的法医和临床病理谱
Michael S Pollanen1, K A Sarathchandra Kodikara2, Fabio A Tironi3
1Ontario Forensic Pathology Service, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada.
Forensic science international
|September 6, 2025
概括
致命的脊椎动脉问题, 包括中风和出血, 与部创伤和遗传因素有关. 尸检应该检查两段动脉, 并包括基因检测以准确确定死亡原因.
科学领域:
- 法医病理学
- 血管病理
- 遗传学
背景情况:
- 脊椎动脉损伤可能导致严重的神经事件,
- 了解潜在的病理和促成因素对于准确的法医和临床评估至关重要.
研究的目的:
- 研究14个死后病例的临床病理谱.
- 确定导致脊椎动脉相关死亡的潜在病理和病因因素.
主要方法:
- 在14例脊椎动脉受损病例中进行了尸检.
- 内和外脊椎动脉段的组织病理分析.
- 鉴定潜在的病态,包括细分中间动脉病变,创伤性破裂,剖析和动脉样硬化.
主要成果:
- 主要结局结果是脑小心梗塞 (n=8) 和下关节出血 (n=6).
- 最常见的病理是细分性中间动脉病变 (n=5),有时涉及上半导体动脉.
- 部创伤 (50%) 和遗传因素 (21%) 被确定为重要的辅助因素.
结论:
- 获得的 (创伤,部运动) 和遗传因素的结合导致脊椎动脉病变.
- 动脉壁基因的突变是与外部力量相互作用的关键风险因素.
- 建议进行全面的尸检,包括对脊椎动脉片段,中腔动脉和遗传检测的组织学检查.
相关概念视频
Aneurysm II: Clinical Manifestations and Diagnostic Studies
21
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
21
Arteries of the Head and Neck
1.7K
The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
1.7K
The Arch of Aorta
1.0K
The coronary arteries, originating from the ascending aorta, bifurcate from two sinuses located within the ascending aorta. Positioned just above the aortic semilunar valve, these sinuses house essential aortic baroreceptors and chemoreceptors, crucial for maintaining cardiac function. The left coronary artery and the right coronary artery branch off from the left posterior and anterior aortic sinuses, respectively.
Encircling the heart, the coronary arteries form a ring-like structure before...
Encircling the heart, the coronary arteries form a ring-like structure before...
1.0K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
33
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
33
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
37
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
37
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
33
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
33


