通过对PTEN/PI3K/AKT轴的调节,阿兰托拉克可以预防大鼠的激素诱导的良性前列腺增生
Basma G Eid1, Abdulmohsin J Alamoudi1, Alaa Sirwi2
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Biochemical and biophysical research communications
|September 6, 2025
概括
亚兰托拉克 (ALA) 对大鼠的激素诱导的良性前列腺增生 (BPH) 具有保护作用. ALA具有抗氧化,抗炎和促细胞衰退的特性,为BPH提供了潜在的新治疗途径.
科学领域:
- 药理学和毒理学
- 泌尿外科
- 自然产品研究
背景情况:
- 目前的良性前列腺增生 (BPH) 治疗有显著的不良影响.
- 在动物模型中, (TEST) 是诱导BPH的常见方法.
- 阿兰托拉克 (ALA) 是一种具有潜在治疗功能的天然化合物.
研究的目的:
- 在老鼠模型中评估alantolactone (ALA) 对激素 (TEST) 诱导的良性前列腺增生 (BPH) 的保护作用.
- 调查ALA作用的潜在机制,包括其抗氧化,抗炎和促死作用.
主要方法:
- 在Wistar小鼠中使用丸激素 (TEST) 诱导良性前列腺增生.
- 小鼠接受了不同剂量的alantolactone (ALA) 或载体治疗.
- 评估了前列腺指数,组织病理变化,氧化应激标志物,炎症标志物 (NF-κB,TNF-α,IL-6),亡标志物 (Bax,Bcl-2),以及PTEN/ PI3K/ AKT通路.
主要成果:
- 阿兰托拉克 (ALA) 显著防止前列腺指数和组织病理损伤的升.
- 通过抑制脂质过氧化和恢复抗氧化酶活性,ALA表现出强烈的抗氧化作用.
- 它可以抑制炎症标志物,促进细胞灭亡,同时调节PTEN/PI3K/AKT信号通路.
结论:
- 在老鼠中,alantolactone (ALA) 具有显著的抗激素 (TEST) 诱导的良性前列腺增生 (BPH) 的保护作用.
- ALA的治疗效果归因于其抗氧化,抗炎,促细胞衰竭和抗增殖的特性.
- 对PTEN/PI3K/AKT轴的调节是 ALA在BPH中的保护作用的关键机制.
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