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相关概念视频

Hedgehog Signaling Pathway02:33

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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在TEAD凝聚物中的内源YAP/TAZ分离调节Hippo反应

Tianxin Zhu1, Huan Li2, Siwei Mao3

  • 1Lingang Laboratory, Shanghai 200031, China; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201203, China.

Molecular cell
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概括

这项研究表明,TEAD凝聚物组织YAP/TAZ信号传递,作为转录激活的枢纽. 了解TEAD凝聚物的动态是开发向治疗的关键.

关键词:
一个 TEAD其他类型YAP/TAZ 公司生物分子凝聚物抑制剂

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Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit
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Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit
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科学领域:

  • 细胞生物学
  • 分子生物学
  • 生物化学

背景情况:

  • YAP/TAZ是对河马通路至关重要的转录联合激活剂.
  • 在转录激活中YAP/TAZ相分离的作用已被提出,但尚未完全理解.
  • 内源YAP/TAZ-TEAD凝聚物的生物分子基础尚不清楚.

研究的目的:

  • 研究YAP/TAZ-TEAD凝聚物的内源形态和功能.
  • 阐明TEAD蛋白在相分离和YAP/TAZ招募中的作用.
  • 探讨TEAD凝聚剂对TEAD抑制剂发展的影响.

主要方法:

  • 对人类细胞系内源性YAP/TAZ-TEAD凝结体形态的分析.
  • 研究TEAD蛋白的相分离潜力.
  • 评估TEAD相互作用损失对YAP/TAZ凝结物的影响.
  • 评估VGLL4在TEAD抑制机制中的作用.

主要成果:

  • YAP/TAZ是被 TEAD 凝聚物招募的客户蛋白.
  • TEAD蛋白具有内在的相分离能力.
  • TEAD凝聚剂作为活动YAP和转录标记物的组织枢纽.
  • VGLL4被确定为TEAD中心口袋抑制剂的关键调节剂.

结论:

  • 在空间调节 YAP/TAZ 信号中, TEAD 凝结体起着基本的作用.
  • 对于理解TEAD生物学来说, TEAD凝结物的动态非常重要.
  • 针对TEAD凝聚剂为YAP/TAZ相关疾病提供了潜在的治疗策略.