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Updated: Sep 18, 2025

A Mass Spectrometry-Based Proteomics Approach for Global and High-Confidence Protein R-Methylation Analysis
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在自身免疫性疾病中作为关键的翻译后蛋白质修饰的 lysine 单甲基化

Kosuke Yamaguchi1, You-Yun Hu1, Kaito Kawajiri1

  • 1Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

The Journal of biological chemistry
|September 6, 2025
PubMed
概括

系统性红斑狼 (SLE) 与素单甲基化减少有关,影响B细胞成熟和抗体产生. 这种表观遗传失调为新的狼治疗提供了潜在的目标.

关键词:
B细胞的分化附带体自体免疫性疾病基因子素单甲基化翻译后修改 (PTM)系统性红斑狼

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Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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