通过NF-κB通路改善肠道屏障和炎症调节,Pleurotus citrinopileatus多糖改善DSS诱导的性结肠炎
Chao Li1, Lu Zhao2, Shichao Yu2
1Department of Neurology, Stroke Center, The First Hospital of Jilin University, Changchun, 130021, China.
International journal of biological macromolecules
|September 6, 2025
概括
来自Pleurotus citrinopileatus的新型多糖体CP-2-2显示出对性结肠炎 (UC) 的显著治疗潜力. 它通过抑制NF-κB通路来缓解炎症并保护肠道屏障.
科学领域:
- 药理学
- 自然产品化学
- 免疫学
背景情况:
- 性结肠炎是一种慢性炎症性肠病,治疗选择有限.
- 自然化合物因其免疫调节和抗炎性质而受到越来越多的研究.
研究的目的:
- 研究从Pleurotus citrinopileatus中分离出的多糖在硫酸 (DSS) 诱导的性结肠炎上的药理作用.
- 阐明隔离的多糖的基本作用机制.
主要方法:
- 使用色谱技术从Pleurotus citrinopileatus中分离和净化多糖体CP-2-2.
- 描述CP-2-2的组成,分子量和结构特征 (FTIR,甲基化).
- 使用DSS诱导的UC小鼠模型进行体内研究以评估治疗疗效和体内测试以研究细胞机制.
主要成果:
- 在小鼠中,CP- 2-2显著缓解了UC症状,包括体重减轻,疾病活性指数 (DAI) 和结肠长度增加.
- CP-2-2 抑制了促炎性细胞因子的产生,并调节了 NF-κB 信号通路.
- 用CP-2-2治疗改善了肠道病理损伤,改善了肠道屏障功能,并在体外抑制了细胞亡和铁亡.
结论:
- 来自Pleurotus citrinopileatus的多糖化合物CP-2-2显示出对DSS诱导的大肠炎的显著保护作用.
- 它的治疗潜力部分归因于抑制NF-κB信号传递和保护肠上皮细胞.
- CP-2-2 是治疗性结肠炎的一种有前途的功能药物.
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