来自Isatidis Radix的新型酸性多糖:斑马鱼的结构特征和免疫调节作用
Tong Li1, Mengting Lai1, Metsawur Memtimin1
1Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Provincial Key Laboratory of Functional Substances in Traditional Chinese Medicine Formulae and Innovative Drug Discovery, Nanjing University of Chinese Medicine, Nanjing, 210023, PR China.
International journal of biological macromolecules
|September 6, 2025
概括
本研究详细介绍了来自Isatidis Radix的天然多糖体IRPS-TE-3的免疫调节作用. 该化合物在斑马鱼中表现出显著的免疫增强和抗炎性质,没有毒性.
科学领域:
- 免疫学和天然产品化学
- 用于健康应用的生物活性天然化合物的探索
背景情况:
- 免疫系统的平衡对于健康至关重要,
- 自然多糖因其多样化的生物活动而为免疫调节提供了有前途的途径.
研究的目的:
- 从Isatidis Radix中分离出来的多糖体IRPS-TE-3的结构.
- 使用斑马鱼模型评估IRPS-TE-3的免疫调节活性和安全性.
主要方法:
- 使用包括NMR光谱,形态分析和单糖组成分析在内的技术来阐明IRPS-TE-3.
- 在斑马鱼胚胎中评估IRPS-TE-3的毒性和免疫调节作用以及氨醇诱导的免疫损伤模型.
主要成果:
- 鉴定了IRPS-TE-3的结构,发现了复杂的多糖骨干和分支链.
- 在斑马鱼胚胎中,IRPS-TE-3没有表现出毒性.
- 聚糖在斑马鱼中显著增强了免疫细胞数量,减少了炎症因子和反应性氧物种 (ROS),减少了亡,并保护了肠道屏障的完整性.
结论:
- IRPS-TE-3具有显著的免疫调节活性,可以安全食用.
- 这些发现支持IRPS-TE-3作为免疫健康和产品开发的功能成分的潜力.
相关概念视频
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