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J F Bastidas¹, M Martínez de Bourio-Allona², A Roteta Unceta Barrenechea³

¹Servicio de Medicina Nuclear, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain; Servicio de Medicina Nuclear, Axxis Hospital de Especialidades, Quito, Ecuador; Grupo de Trabajo de Oncología de la SEMNIM, Spain.

Revista espanola de medicina nuclear e imagen molecular

|September 6, 2025

概括

使用新型射线追踪器进行先进的PET/CT成像可以改善乳腺癌的诊断和个性化治疗. 分子成像为各种亚型和转移提供了卓越的准确性,指导临床决策.

科学领域:

癌症学
核医学
放射性药物化学

背景情况:

乳腺癌是全球领先的瘤,其分子亚型多样,影响患者的治疗结果.
阳离子发射断层扫描/计算机断层扫描 (PET/CT) 对于乳腺癌的治疗至关重要,为诊断,分期和治疗反应提供了洞察力.
标准的放射标记物如[¹⁸F]-氧糖具有局限性,特别是在侵袭性叶状癌等特定亚型中.

研究的目的:

审查PET/CT和新型放射性药物在乳腺癌治疗中的演变作用.
突出分子成像技术的进步以实现个性化诊断,分期和治疗监测.
讨论新兴的放射性标记物及其在乳腺癌亚型和转移检测中的具体应用.

主要方法:

对乳腺癌中PET/CT应用的当前文献的综述.
讨论已知和新型放射性药物,包括[F]-氧糖,16α-[F]-17β-雌激素,[Ga]-FAPI,[Zr]-特拉斯图祖马布和[F]-纳.
探索像HER2,纤维细胞激活蛋白,PSMA和GRPR等成像目标.

主要成果:

与氧糖相比,16α-[¹⁸F]-17β- Estradiol和[⁶⁸Ga]-FAPI在侵袭性叶状癌中具有更好的效果.
针对HER2的药物如[⁸⁹Zr]-trastuzumab使瘤异质性的准确评估成为可能.
[18F]-NaF有效检测骨转移,并且正在确定PSMA和GRPR等新目标.

结论:

用PET/CT进行分子成像对于个性化乳腺癌治疗策略至关重要.
先进的放射性药物提高了诊断准确性,并优化了各种乳腺癌情景的临床决策.
对新的成像点的持续研究有望进一步改善患者护理和治疗效果.

关键词:

在线信息美国德国政府在FES 在HER2 国际贸易公司在 NST 乳腺癌母亲癌症

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