用高流量鼻空气或风扇治疗呼吸困难 - 随机对照交叉试验
Sirpa Leivo-Korpela1, Heidi A Rantala2, Lauri Lehtimäki3
1Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland and Department of Palliative Care Centre and Home Hospital Services, Tampere University Hospital, The Wellbeing Services County of Pirkanmaa, Finland.
Journal of pain and symptom management
|September 6, 2025
概括
高流鼻疗法 (HFNT) 和风扇疗法在晚期癌症患者中提供类似的喘息缓解. 这两种方法都是可行的,耐受性很好,患者的偏好指导了干预的选择.
科学领域:
- 缓和护理
- 呼吸系统医学
- 癌症学
背景情况:
- 高流鼻治疗 (HFNT) 是严重呼吸不良的潜在干预措施.
- 它与其他治疗方法,如风扇治疗,在息治疗中的比较有效性尚未得到充分证实.
- 这项研究解决了非低血症癌症患者的证据需求.
研究的目的:
- 为了比较HFNT与空气治疗对缓解呼吸障碍的有效性和可行性.
- 评估对非低血症癌症患者的影响.
- 评估患者报告的两种干预措施的结果和不良事件.
主要方法:
- 进行了前性随机对照交叉试验.
- 患者接受了30分钟的HFNT与空气和风扇治疗.
- 使用数值评分表 (NRS) 测量呼吸障碍;二次评估包括整体益处和不良事件.
主要成果:
- 使用空气和风扇治疗的HFNT均显著降低了呼吸障碍得分 (P<0.05).
- 这两项干预措施的呼吸障碍NRS变化中位数为-1. 0, 两者之间没有统计学上显著的差异 (P=0. 935).
- 超过一半的患者发现这两种疗法都有益且耐受良好,没有报告任何显著的不良事件.
结论:
- 在非低血症晚期癌症患者中,HFNT与空气和风扇疗法在缓解呼吸障碍方面具有可比的有效性.
- 这两种干预都是可行的, 提供轻微的缓解, 没有显著的不良影响.
- 由于治疗结果相似,应优先考虑患者的偏好.
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