功能神经障碍中的运动功能障碍机制:叙述性综述
Alfred Pak-Kwan Lo1, Maryam Homayoun2, Alec J Jamieson1
1Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia.
Neuroscience and biobehavioral reviews
|September 6, 2025
概括
功能神经障碍 (FND) 运动症状如虚弱和震源于行动预测,压力敏感性和自上而下的控制问题. 了解这些机制是开发有效FND治疗的关键.
科学领域:
- 神经科学
- 精神病学
- 临床神经学
背景情况:
- 功能神经障碍 (FND) 经常表现为残疾的运动症状,包括虚弱和.
- 在FND中这些运动功能障碍的确切机制依据仍然不完全理解.
- 现有研究强调了FND对患者日常生活和功能能力的重大影响.
研究的目的:
- 提供FND运动功能障碍的机制基础的综合和最新审查.
- 综合各种研究方法的发现,包括神经影像,生理学,遗传学,大脑刺激和行为研究.
- 建立一个理解和潜在治疗FND运动症状的框架.
主要方法:
- 在MEDLINE和PsycINFO数据库中进行系统的文献搜索.
- 在FND调查运动功能障碍的相关研究中采用了包括标准.
- 综合了168项选定的研究结果,涵盖了各种研究方法.
主要成果:
- 与健康对照组相比,患有FND的患者表现出行动预测能力受损,对身体信号的意识受损.
- 在FND患者中观察到更高的压力敏感性和情绪和运动系统之间的更强的联系.
- 行动选择和过度自我监测中的异常表明FND的自上而下的控制机制存在失调.
结论:
- 在FND中,运动症状与信息处理的不同模式有关,包括行动推断的困难和自我监测的改变.
- 情绪和运动系统之间的相互作用,以及压力过敏,导致FND的运动障碍.
- 鉴定到的机制性见解为开发针对FND运动症状的有针对性的治疗干预提供了潜在的框架.
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