基于生物标志物的中年农村人口心力衰竭前查
Yuichiro Mori1, Shunsuke Natori2, Toshio Arai3
1Department of Cardiovascular Medicine, Furano Kyokai Hospital, Furano, Japan; Department of Internal Medicine, Furano Kyokai Hospital, Furano, Japan; Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Journal of cardiology
|September 6, 2025
概括
在公共卫生计划中,使用N-终端亲B (NT-proBNP) 进行心力衰竭前查,发现7.5%的个体水平升高. 然而,只有不到一半的人参加了后续咨询,这表明需要改善选后的途径.
科学领域:
- 心脏病学
- 预防医学
- 生物标志物研究
背景情况:
- 准则建议在危险人群中对心力衰竭前期 (心力衰竭前期) 进行基于生物标志物的查.
- 预防性查对于无症状的HF前期至关重要,但实际实施数据有限.
- 本研究研究了一项区域性HF前查计划, 整合到年度健康查中.
研究的目的:
- 在一般中年人群中确定高N终端亲B (NT-proBNP) 的患病率.
- 在NT-proBNP升高的个体中确定相关的心声学发现.
- 评估在整个查到咨询路径中对HF的坚持.
主要方法:
- 在日本Furano市接受HF前查的1585名年龄在40-74岁的人的回顾性分析.
- 纳入每年健康查的NT-proBNP检测;针对≥125 pg/mL的水平,转诊进行心脏病咨询和心声扫描.
- 评估NT-proBNP水平,心声学数据和后续咨询出席率.
主要成果:
- 观察到近乎完美的NT-proBNP测试依从性 (99. 6%).
- 在7. 5% (118/1585) 的参与者中发现NT- proBNP水平升高 (≥125 pg/ ml),与年龄,女性性别和血压升高有关.
- 只有46.6% (55/118) 的人参加了心脏病咨询;40%的被评估者有异常的心声检查结果.
结论:
- 将NT-proBNP测试整合到公共卫生查中是可行的,并且获得了很高的遵守率.
- 该倡议确定了中年人口中很大一部分患有HF前的指标, 提供了预防机会.
- 在专家咨询方面存在很大差距,因此需要优化查后的途径,以充分利用全民高风前查的好处.
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