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免疫检查点抑制剂CEMIPLIMAB诱导的NMOSD长期治疗中的作用

Fien Oelbrandt¹, Romain Marignier², Bénédicte Dubois¹

¹Department of Neurology, University Hospitals Leuven, Leuven, Belgium.

Clinical neurology and neurosurgery

|September 6, 2025

概括

这份病例报告详细介绍了一名患有戈林·戈尔茨综合征的患者,在接受塞米普利马布治疗后患有神经髓炎光谱障碍 (NMOSD). 报告强调了免疫检查点抑制剂诱导的NMOSD需要长期管理策略.

科学领域:

神经免疫学
皮肤病学
癌症学

背景情况:

戈林·戈尔茨综合征是一种与多重基底细胞癌 (BCCs) 相关的遗传性疾病.
免疫检查点抑制剂 (ICI) 如塞米普利马布用于治疗晚期癌症.
视神经炎光谱障碍 (NMOSD) 是一种罕见的自身免疫性疾病,影响中枢神经系统.

研究的目的:

在患有戈林·戈尔茨综合征的患者中报告首例因塞米普利马布引起的NMOSD病例.
讨论长期ICI诱导的NMOSD管理的挑战.
为预防NMOSD复发提出潜在的维持疗法.

主要方法:

一位患有戈林戈尔茨综合征的54岁女性病人的病例介绍.
对ICI诱导的NMOSD和管理策略的文献审查.
对NMOSD进行临床评估和诊断工作.

主要成果:

在治疗BCC后,该患者产生了阳性NMOSD的aquaporin-4抗体 (AQP4- Ab).
这是首例与塞米普利马布相关的NMOSD病例.
目前的指导方针侧重于急性治疗,而ICI诱导的NMOSD的长期管理尚未解决.

结论:

塞米普利马布可能会诱导NMOSD,即使是患有Gorlin Goltz综合征等基因疾病的患者.
长期维持治疗对于预防ICI诱导的NMOSD复发至关重要.
利图西马布或托西利祖马布是这些患者的潜在维持选择.

关键词:

其他药物:免疫检查点抑制剂与免疫相关的不良事件视神经炎光谱障碍

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