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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Updated: Sep 8, 2025

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

联盟概况:甲基化,成像和神经发展 (MIND) 联盟

Isabel K Schuurmans¹, Rosa H Mulder¹, Vilte Baltramonaityte²

¹Department of Child and Adolescent Psychiatry and Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.

Molecular psychiatry

|September 6, 2025

概括

甲基化,成像和神经发育 (MIND) 联盟研究了DNA甲基化与大脑发育的关系. 这种大型的协作努力使用纵向数据来理解表观遗传对神经发育和精神病现象的影响.

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相关实验视频

Last Updated: Sep 8, 2025

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

Molecular Imaging of Human Brain Organoids Using Mass Spectrometry

Molecular Imaging of Human Brain Organoids Using Mass Spectrometry

Published on: September 27, 2024

Profiling Maternal Behavior Responses During Whole-Brain Imaging

Profiling Maternal Behavior Responses During Whole-Brain Imaging

Published on: January 24, 2025

科学领域:

神经科学
遗传学
发育生物学

背景情况:

像DNA甲基化这样的表观遗传过程是影响大脑表型的基因环境相互作用的关键.
了解外围表观遗传模式与个体大脑差异的关系是有限的,特别是在发育背景下.
现有研究主要使用成年人的横截面数据,缺乏发展视角.

研究的目的:

建立甲基化,成像和神经发育 (MIND) 联盟,专注于发育神经成像表观遗传学.
通过多个队列分析促进协作型,强大的发展研究.
通过使用长度儿科数据,推进DNA甲基化-大脑动态的理解.

主要方法:

整合16个国际队列与纵向DNA甲基化和神经成像数据.
在整个发育过程中 (从出生到成年) 收集DNA甲基化 (血液,口腔,唾液) 和MRI的重复测量.
采用共享的管道和开放的科学实践.

主要成果:

MIND整合了来自N=12,877 (DNAm),N=10,899 (神经成像) 和N=6074 (组合) 参与者的数据.
数据涵盖了21年的五个时间点,
在多个时间点和研究类型中三角化关联以揭示动态关系.

结论:

MIND为神经影像表观遗传学提供了一个独特的大规模发育数据集.
该联盟旨在产生对外围DNA甲基化和大脑关系的新见解.
研究结果将阐明表观遗传对神经发育和精神病现象的贡献.