活细胞的等离子膜的长距离粘度通过剪切驱动的流量方法测量
Yuka Sakuma1, Kazunori Yamamoto2, Saya Ichihara3
1Department of Physics, Graduate School of Science, Tohoku University 6-3 Aoba, Aramaki, Aoba, Sendai, 980-8578, Japan.
Biophysical journal
|September 7, 2025
概括
这项研究首次测量了活细胞中的长距离血粘度. 我们发现它比短距离粘度高出四个数量级,
科学领域:
- 生物物理
- 细胞生物学
- 膜动力学
背景情况:
- 血粘度是细胞功能的关键,具有不同的短距离和长距离组件.
- 短距离粘度与分子运动有关,并影响信号传输.
- 长距离粘度会影响细胞迁移和分裂,受皮质等细胞结构的影响.
研究的目的:
- 测量活细胞中等离子膜的长距离粘度.
- 研究细胞结构的作用,特别是行为细胞骨,在确定膜粘度.
主要方法:
- 在C. elegans胚胎的血上施加外力.
- 观察到的膜流动模式,特别是流,在抑制了actin聚合后.
- 利用水力动力学模型根据观察到的流量量化长距离粘度.
主要成果:
- 完整的细胞没有在外力下诱导膜流动.
- 阻断了活性质聚合,导致了流.
- 测量到的远程粘度比短程粘度和DOPC膜高四个数量级.
结论:
- 活细胞等离子膜的远程粘度明显高于以前的理解.
- 在建立这种高远程粘度方面,actomyosin细胞骨起着至关重要的作用.
- 这些发现为控制细胞力学和动态的生物物理性质提供了新的见解.
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