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瘤微环境中的机械和建筑信号对黑色素瘤的影响

Zerin Mahzabin Khan^1,2,3, Alejandro Rossello-Martinez⁴, Michael Mak^4,1

¹Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA.

Advanced healthcare materials

|September 7, 2025

概括

瘤微环境中的机械力量和原结构驱动着状黑色素瘤的进展. 抑制乙聚合可能为这种侵袭性皮肤癌提供新的治疗策略.

科学领域:

癌症学
生物材料科学
细胞生物学

背景情况:

状黑色素瘤不同于暴露在阳光下的类型,在阳光较低的区域发生,机械应力较高.
黑色素瘤转移包括通过密的瘤层侵入,遇到原和机械力量.
这些微环境线索在状黑色素瘤中的具体作用尚未完全理解.

研究的目的:

研究机械和建筑线索对状黑色素瘤发病的影响.
开发和使用模拟黑色素瘤瘤微环境的新型3D体外平台.
量化评估细胞对机械压缩和原结构的反应.

主要方法:

使用一个带有原的3D体外平台.
培养和机械压缩来自患者的人类状黑色素瘤和小鼠黑色素瘤细胞.
分析了包括活力,DNA损伤,增殖,入侵和形态在内的细胞反应.
微流体,机械模拟和药物抑制提供了机械洞察力.

主要成果:

机械压缩诱导了黑色素瘤细胞的DNA损伤和修复机制.
与捆绑的原相互作用促进了恶性突起的细胞表型.
这些反应的关键媒介被确定为actin聚合和收缩性.

结论:

机械力量和原结构显著影响状黑色素瘤细胞的行为.
向actin动力学可能是一个潜在的治疗策略.
这种3D平台有效地模拟瘤微环境,

关键词:

性黑色素瘤生物物理信号原结构机械压缩机械生物学瘤微环境瘤球体

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