用于增强免疫治疗癌症的双模式混合排放激活注射水溶液
Zewei Wang1, Xixi Jing2, Danqi Zhang2
1Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China.
Advanced healthcare materials
|September 7, 2025
概括
这项研究引入了一种新的血激活水溶,通过产生反应性氧和物种 (RONS) 来有效增强对瘤的免疫反应.
科学领域:
- 生物医学工程
- 免疫学
- 血物理
背景情况:
- 通过反应性氧和物种 (RONS) 的瘤免疫疗法,冷大气等离子体 (CAP) 是有前途的.
- CAP的临床应用受到RONS生成和交付方面的挑战的限制.
- 在癌症治疗中开发有效的RONS策略至关重要.
研究的目的:
- 为增强抗瘤免疫反应提出双模式混合排放的激活酸水溶 (PAH SA).
- 在水溶中研究气态RONS转化为水性RONS.
- 在体外和体内评估拟议方法的有效性.
主要方法:
- 使用双模式混合等离子系统,将臭氧 (O3) 和氧化 (NOx) 模式结合起来.
- 通过气液反应生成了激活酸盐水溶 (PAH SA).
- 在体外测试中评估了癌细胞死亡和巨细胞分化.
- 在体内研究中使用B16F10黑色素瘤模型来评估瘤生长抑制和免疫反应.
主要成果:
- 与单模激活水溶相比,混合PAHSA在癌细胞中诱导免疫细胞死亡的效果更强.
- 混合PAHSA有效地调解了M2类巨细胞向M1类巨细胞的两极分化.
- 在体内研究显示显著抑制B16F10黑色素瘤的生长.
- 在混合PAHSA治疗中观察到增强的T细胞介导的抗瘤免疫反应.
结论:
- 双模混合排放激活基酸盐 (Hybrid-PAH SA) 是癌症免疫治疗的有希望的策略.
- 这种方法有效地增强了RONS的产生和传递,从而改善了抗瘤效果.
- 混合PAHSA为基于血的癌症治疗提供了一个潜在的平台.
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