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动脉网定向对长期血栓生长风险的影响:使用液体-固体相互作用的数值研究

Songling Fu¹, Zhaokun Li², Xinhui Liu³

¹School of Computer Science and Technology, Southwest University of Science and Technology, Mianyang 621010, China.

Computer methods and programs in biomedicine

|September 7, 2025

概括

较大的动脉网角增加流动干扰和血栓风险. 纳入血管壁弹性可以改善年轻患者对这种纤维肌肉发育不良病变的评估.

科学领域:

心血管研究的心血管研究.
生物医学工程生物医学工程
医学成像分析分析医学成像分析

背景情况:

冠状动脉网 (CaW) 是一种罕见的纤维肌力发育不良病变.
在年轻患者中,CaW与血栓塞栓事件有关.
CaW诱导的血液动力学障碍有助于血栓形成,但形态学对长期风险的影响尚不清楚.

研究的目的:

调查状动脉网 (CaW) 形态对血液动力学障碍和血栓形成的影响.
评估CaW角度和血管壁弹性的对血栓形成风险的影响.

主要方法:

开发了针对患者的三维数值模型,用不同的CaW角度 (30°,60°,90°) 测试动脉.
嵌入的血管壁弹性和血栓生长机制使用流体结构相互作用模拟.
分析了墙壁变形,应力,流场和墙壁剪切应力.

主要成果:

较大的CaW角度增加了墙壁变形和应力,表明机械负载更高.
降低了内动脉的速度,并产生了具有更大的角度的循环回收区域.
血栓生长模型显示60°和90°的形成明显,硬壁模型显著低估了血栓区域.

结论:

较大的CaW角与增加的流动干扰和高血栓风险有关.
角变化影响血栓分布;血管壁弹性对于准确的风险评估至关重要.
临床评估 carotid 几何和壁弹性可以优化血栓风险评估和指导干预.

关键词:

动脉动脉网动脉动脉网流体结构相互作用的相互作用血液动力学血液动力学血栓形成的形成.血管壁的弹性血管壁的弹性

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