对于NIR-II激活和瘤特异性的热电动和光热疗法的pH触发的肖特基异质连接
Jie Meng1, Shuang Xie1, Zhanlin Zhang1
1Institute of Biomedical Engineering, College of Medicine, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, PR China.
Journal of colloid and interface science
|September 7, 2025
概括
工程火电纳米粒子 (NP) 提供pH触发的瘤疗法,增强火电动力学疗法 (PEDT) 和光热疗法 (PTT),同时最大限度地减少非目标毒性,以改善癌症治疗.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 热电动疗法 (PEDT) 面临着低效率和目标外毒性挑战.
- 现有的疗法需要高温或表现出有限的瘤透.
研究的目的:
- 开发pH触发的火电纳米粒子 (NP),用于增强协同PEDT和轻度光热疗法 (PTT).
- 改善瘤选择性,减少癌症治疗中的非标毒性.
主要方法:
- 工程 BaTiO3 (tBT) 核心纳米颗粒涂上MoO3,然后进行化和PEGylation (tBT@HMO-PEG).
- 利用pH触发的Schottky异质连接结构来产生瘤选择性的ROS.
- 在使用NIR-II光的瘤携带小鼠模型中研究了NP性能.
主要成果:
- 设计的NP显示了pH触发稳定性,高效的NIR-II吸收和增强的光热转换.
- 异质连接的形成改善了电子孔分离和ROS生成,导致选择性瘤细胞膜潜在破坏.
- 实现深度瘤透和广泛的ROS分布,从而产生强大的抗瘤疗效,毒性最小.
结论:
- 热电纳米颗粒中的pH触发的舒特基异质连接为精确有效的瘤治疗提供了一个有前途的策略.
- 开发的NP减轻了非目标毒性,提高了PEDT和PTT组合的安全性和有效性.
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