绘制VEXAS综合征中的传染性负担:系统审查和预防的理由
Valentine Ribier1, Jérôme Hadjadj2, Vincent Jachiet2
1Service de Médecine Interne et Immunologie Clinique, Centre Hospitalier Universitaire d'Angers, Angers, France.
The Lancet. Rheumatology
|September 7, 2025
概括
在VEXAS综合征患者中,感染是常见的和严重的. 预防策略,包括疫苗接种和预防药物,对于管理VEXAS综合征的感染风险至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 感染是维克萨斯综合征发病率和死亡率的重要原因.
- 了解感染负担对于患者管理至关重要.
研究的目的:
- 系统地审查和描述VEXAS综合征中的传染性负担.
- 提出基于证据的预防感染策略.
主要方法:
- 对57项研究的系统综述,包括813名患有VEXAS综合征的患者.
- 分析感染类型,病原体,严重程度和结果.
主要成果:
- 在VEXAS综合征中,感染频繁 (40-60%严重,6-15%致命).
- 肺部,皮肤感染和细菌病是最常见的.
- 机会性病原体是常见的,这表明内在的免疫功能障碍.
结论:
- 在高风险患者中,应考虑使用co-trimoxazole,valaciclovir和posaconazole进行预防.
- 建议对常见病原体进行疫苗接种.
- 整合感染风险管理对于维克萨斯综合征护理至关重要.
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