在不同的免疫干扰中影响单克隆抗体药理学的因素

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Updated: Jan 18, 2026

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Purification and Analytics of a Monoclonal Antibody from Chinese Hamster Ovary Cells Using an Automated Microbioreactor System

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Jonathon DeBonis1, Anthony E Davis1, Zeshi Wang1

  • 1Department of Bioengineering, Rice University, Houston, TX, USA.

Journal of controlled release : official journal of the Controlled Release Society
|September 7, 2025
PubMed
概括

生物药物测试的小鼠模型显示单克隆抗体 (mAb) 药理动力学 (PK) 中存在显著差异. BCD和RAG2小鼠为人类提供比BL6和NSG菌株更准确的PK预测.

关键词:
免疫系统的淘汰.数学建模的数学建模单克隆抗体是一种单克隆抗体.药理动力学 药理动力学

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