帝国素通过抑制巨细胞中AIM2-介导的GSDMD Pyroptosis来缓解肠道纤维化

Sheng Li1, Fangqing Zhu2, Yao Xie3

  • 1Guangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Department of Gastroenterology, Yuebei People's Hospital, Shantou University Medical College, Shaoguan, China.

概括

Imperatorin (IMP) 通过向巨细胞中的AIM2炎症酶途径来抑制Gasdermin D (GSDMD) 介导的热,为克罗恩氏病相关的肠纤维化提供了潜在的治疗方法.