大动脉的功能和大动脉扩张与幼儿时代双侧大动脉有关
Jakob Boesgaard Norsk1, Anne-Sophie Sillesen2, Maria Munk Pærregaard3
1Department of Cardiology, Copenhagen University Hospital Herlev-Gentofte Hospital, Herlev, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
概括
双主动脉 (BAV) 在儿童中导致主动脉吐和扩张到3岁. 这表明一种固有的大动脉壁敏感性,而不仅仅是改变了血液流动,导致了与BAV相关的大动脉扩大.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 心血管成像 - 心血管成像
- 遗传性心脏病是一种先天性心脏病.
背景情况:
- 双主动脉 (BAV) 的自然史及其与大动脉扩张的关联尚未完全理解.
- 不确定性存在于BAV中的大动脉扩张是由于固有的大动脉壁敏感性或改变的血液动力学.
研究的目的:
- 在新生儿BAV诊断的学龄前儿童中,描述门功能和大动脉扩张的演变.
- 为了比较BAV患者的大动脉尺寸和门功能与三大动脉控制器.
主要方法:
- 在哥本哈根婴儿心脏研究 (n>25,000) 中对被诊断患有BAV的儿童进行了后续研究.
- 在BAV病例 (n=128) 和对照 (n=88) 的3岁时进行心声扫描.
- 大动脉直径使用Z分数进行正常化.
主要成果:
- 在BAV病例中,大动脉反的患病率从新生儿的15.6%增加到随访时的24.2% (P < .05).
- 在随访时,BAV病例和对照人群之间对大动脉流速没有显著差异.
- 在BAV病例中与新生儿和3年随访的对照群相比,大动脉直径显著增加 (瓦萨尔瓦鼻腔,鼻管结,上升大动脉) (P < .001).
结论:
- 在新生儿BAV诊断的儿童中,超过一半的儿童在3岁时表现出大动脉扩张 (Z评分≥2) .
- 这些发现支持BAV中大动脉壁的固有易感性,超出了改变的流动力学.
- 在儿科BAV中早期发现和监测大动脉扩张至关重要.
相关概念视频
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
420
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
420
01:15Aortic Regurgitation I: Introduction
504
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
504
01:16Heart Valves
11.2K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
11.2K
01:22Mitral Stenosis I: Introduction
485
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
485
01:27Mitral Valve Prolapse I: Introduction
393
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
393
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
223
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
223