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毛囊T辅助细胞 (T_FH):从生理到病理的衰老

Laura de Lisio¹, Remo Poto², Laura Andreea Ceparano¹

¹Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.

European journal of internal medicine

|September 7, 2025

概括

衰老会损害免疫功能,导致感染风险增加和慢性炎症. 本综述探讨了T毛囊辅助细胞 (T_FH) 和它们的调节性对应细胞 (T_FR) 如何随着年龄的增长而变化,影响健康和疾病风险.

科学领域:

免疫学免疫学免疫学
老年学是一门学科.
细胞生物学细胞生物学

背景情况:

全球老年人口正在迅速扩大,伴随着与年龄相关的免疫系统衰退 (免疫衰变).
免疫发生增加了对感染,自身免疫性疾病和慢性炎症状况 (如炎症) 的易感性.
与年龄相关的免疫功能障碍背后的机制,特别是涉及特定的T细胞子集,仍然不完全理解.

研究的目的:

审查T毛囊辅助 (T_FH) 细胞中与年龄相关的细胞和分子变化.
为了检查T_FH与T毛囊调控 (T_FR) 细胞比率与衰老的变化.
讨论T_FH细胞,T_FR细胞和与年龄相关的心血管和神经退行性疾病之间的潜在联系.

主要方法:

文献综述侧重于对T_FH和T_FR细胞在衰老中的研究.
在人类和动物模型中分析T_FH细胞表型和功能的与年龄相关的变化.
检查T_FH/T_FR细胞动态和与年龄有关的疾病之间的关联.

主要成果:

与T_FH细胞表型和功能的与年龄相关的变化在人类和小鼠中都很明显.
功能障碍的T_FH细胞和改变的T_FH/T_FR比率与流行老年疾病有关.
T_FH细胞通过调节B细胞抗体的产生,在免疫平衡中发挥作用.

结论:

与T_FH和T_FR细胞的年龄相关的变化有助于免疫功能障碍和炎症.
在衰老期间,T_FH/T_FR平衡对于维持免疫平衡至关重要.
对T_FH细胞的进一步研究可能会揭示与年龄有关的心血管和神经退行性疾病的治疗点.

关键词:

衰老,炎症,以及其他疾病.CD4 (((+) 是一个单体.生殖中心 (CG)燃烧起来的火焰在T毛囊辅助器 (T(FH)) 中.T 毛囊调节 (T ((FR)) 的作用.的T淋巴细胞.心血管疾病心血管疾病神经退行性疾病的神经退行性疾病

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