岩手 PGS评估和风险沟通 (PARC) 研究的研究概况
Akiko Yoshida1,2, Tomoharu Tokutomi1,2, Nobuhiro Suzumori1,2
1Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University.
这项研究评估了日本工人缺血性中风风险的多基因分数 (PGS). 报告PGS风险的目的是了解其对健康行为的影响,预计未来的后续调查将有所结果.
科学领域:
- 遗传学和公共卫生
- 预防医学 预防医学
- 风险沟通 风险沟通
背景情况:
- 多基因分数 (PGS) 对健康行为修改的影响尚不清楚.
- 岩手PGS评估和风险沟通研究调查了报告基于PGS的缺血性中风风险如何影响健康行为.
研究的目的:
- 检查基于多基因分数 (PGS) 的沟通缺血性中风风险对健康行为的影响.
- 建立一个将PGS纳入个性化预防医学策略的基础.
主要方法:
- 从岩手县的健康检查中招募了2000多名工人.
- 采集健康数据,生物标本和基因分析和PGS计算的问卷,使用东亚模型.
- 随机分配的参与者将收到他们的PGS风险报告 (干预) 或不收到,并计划进行后续调查.
主要成果:
- 达到了58.0%的同意率,招募了2,083名参与者 (80.7%是男性).
- 参与者的年龄分布:18-29岁 (25.2%),30岁 (25.3%),40岁 (24.7%).
- 缺血性中风风险的发病率:基准风险为9.7% (1.0),2.7%的风险为2.1-3.4倍,44.7%的风险为1.4-1.9倍,42.9%的风险为1.0倍以下.
结论:
- 成功收集了2000多个人的健康数据和生物样本.
- 基于多基因分数 (PGS) 披露的缺血性中风风险,行为影响评估持续到2030年.
- 这项研究代表了日本第一个大规模的PGS风险沟通计划,为个性化预防医学提供了洞察力.
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