在住院成年人中预测静脉血栓栓塞:用于开发和验证可实施的实时预后模型的协议
Henry J Domenico1, Benjamin F Tillman2, Shari L Just3
1Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. henry.domenico@vumc.org.
Diagnostic and prognostic research
|September 7, 2025
概括
在医院获得的静脉血栓塞栓症 (HA-VTE) 是住院患者的主要风险. 本研究概述了一项协议,用于开发和验证可靠的HA-VTE预后模型,使用电子健康记录数据进行实时临床使用.
科学领域:
- 临床信息学是一种临床信息学.
- 生物统计学 生物统计学
- 流行病学 流行病学
背景情况:
- 医院获得的静脉血栓塞栓症 (HA-VTE) 是患者发病率和死亡率的重要原因.
- 现有的HA-VTE预后模型缺乏有效临床决策的标准.
- 需要一个验证的,通用的预后模型,用于实时临床应用.
研究的目的:
- 概述一个完善和验证HA-VTE的通用预后模型的协议.
- 开发一个适用于电子健康记录 (EHR) 系统内实时自动化的模型.
- 建立一种可靠的方法来识别HA-VTE风险较高的患者.
主要方法:
- 将对132,561例住院患者的回顾性队列进行分析.
- 后勤回归和LASSO与交叉验证将用于变量选择和模型开发.
- 模型性能将使用歧视 (哈雷尔的C统计) 和校准指标进行评估,并遵循TRIPOD+AI指南.
主要成果:
- 本协议详细说明了HA-VTE预后模型的开发和验证.
- 该模型旨在使用例行收集的EHR数据实现实时实施.
- 严格的统计方法和外部验证队伍将确保模型可靠性.
结论:
- 描述的方法有助于开发,评估和验证HA-VTE的预后模型.
- 结合统计,工程和临床知识,提高了该模型适用于临床实施的适度.
- 一般方法适用于开发其他临床结果的预后模型.
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