个体内视神经外变化和内压力变化:系统性审查和元分析
Henrique Azevedo1, Lia Lucas Neto1,2, David Berhanu1,3,4,5
1Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
概括
视神经外直径 (ONSD) 的测量与内压力 (ICP) 的变化相关. 纵向的ONSD评估可以帮助预测ICP,为患者提供一种非侵入性后续工具.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 关键护理医学 关键护理医学
背景情况:
- 内压力 (ICP) 监测对于管理神经疾病至关重要.
- 随着时间的推移,同一个人内可能会发生ICP的变化.
- 评估ICP的非侵入性方法是非常理想的.
研究的目的:
- 系统地审查在多个时间点使用视神经外直径 (ONSD) 测量的证据.
- 为了评估ONSD作为个人内部ICP变化的指标.
- 为了确定ONSD和ICP与时间的相关性.
主要方法:
- 系统的文献搜索用于反复测量ONSD和ICP的研究.
- 对ONSD和ICP之间的个人内相关系数的元分析.
- 利用超声波进行ONSD测量,并与侵入性ICP数据进行比较.
主要成果:
- 包括5项涉及157名患者的研究.
- 分析显示了显著的个体内ONSD-ICP相关性 (系数=0.62).
- 个别研究报告了强烈的相关性 (0.79-1.00),但具有可变的斜率.
结论:
- 在纵向评估中,ONSD显示出与ICP的显著,主要是线性相关性.
- 个性化的ONSD-ICP相关方程可以实现准确的ICP预测.
- ONSD是监测患者之前具有侵入性ICP测量的宝贵工具.
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