微污染物对活性污泥系统中的微生物群落和抗生素耐药基因的度特异性影响
Jiachen Ma1, Zirui Yin1, Kaoming Zhang1
1State Key Laboratory of Water Pollution Control and Green Resource Recycling, School of Environment, Nanjing University, Nanjing 210023, China.
Journal of hazardous materials
|September 8, 2025
概括
废水中的微污染物会影响微生物群落和抗生素耐药性基因 (ARG). 这项研究揭示了度特定的影响,一些微污染物增加了ARG转移,即使在低水平.
科学领域:
- 环境微生物学环境微生物学
- 污水处理 污水处理 污水处理
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 微污染物在废水中普遍存在,影响微生物群落和抗生素耐药性基因 (ARG).
- 在环境条件下对这些影响的具体度值尚不清楚.
研究的目的:
- 研究六种微污染物对微生物生态和废水中ARG动态的度依赖性影响.
- 确定微污染物引起的微生物群落变化和ARG转移的临界度值.
主要方法:
- 微生物群落暴露在6种微污染物中,其度为5个环境相关度 (0.1500μg/L).
- 分析微生物多样性,社区结构和ARG概况.
- 网络分析以确定ARG宿主和移动遗传元素.
主要成果:
- 微污染物暴露通常会减少微生物多样性.
- 大多数微污染物在0.11μg/L时改变了微生物结构和ARG概况,显示了分类学和抗体变化之间的联系.
- 特里克洛桑 (TCS) 在低度 (0.11μg/L) 时影响了ARG动态,但没有改变群体组成.
- 随着微污染物度的增加,ARG的丰度增加,但乙氨基和纳普罗森显示水平转移风险较低.
- 狄克洛芬雅和TCS在≥10μg/L和≥1μg/L时显著增强了ARG转移.
- 网络分析确定了高风险的ARG宿主 (例如,Burkholderiales,Rhodocyclaceae) 和移动遗传元素.
结论:
- 微污染物诱导的抗生素耐药性的传播是度特异的和化合物特异的.
- 了解这些门对于管理废水中的ARG至关重要.
- 某些微污染物对ARG转移的风险更高,需要有针对性的去除策略.
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