通过液固体技术提升利科紧物的溶解
Shaveta Sharma1, Jyoti Singh1, Sahibpreet Singh1
1Chandigarh College of Pharmacy, Chandigarh Group of Colleges, Landran, Punjab.
Turkish journal of pharmaceutical sciences
|September 8, 2025
概括
液态固体技术通过克服其不良溶解性,改善了柳科的溶解和生物可用性. 优化的配方证明了药物释放的增强,展示了该技术对难以溶解的化合物的潜力.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
背景情况:
- 利科是一种强大的抗氧化剂,由于其脂性性质,具有较差的水溶性和较低的生物可用性,阻碍了治疗疗效.
- 现有的方法,如共溶性和微化,在提高烯的溶解概况方面存在局限性.
研究的目的:
- 使用液态固体紧技术增强利科的溶解特征和生物可用性.
- 为了评估载体类型和药物度对液态固体紧物中烯溶解的影响.
主要方法:
- 使用光谱和物理方法提取和鉴定了白烯.
- 液化紧剂的配方包括各种辅助剂,包括载体 (Avicel PH 101,Fujicalin,Neusilin US2),非挥发性溶剂 (甘油),分解剂 (croscarmellose) 和稀释剂 (乳糖).
- 配方经过压缩前和压缩后的评估,通过粉末X射线衍射 (PXRD) 和里埃变换红外光谱 (FTIR) 评估药物辅助剂相互作用.
主要成果:
- 经PXRD和FTIR分析证实,烯与辅助剂之间没有物理或化学相互作用.
- 所有配制的液态固体紧剂都符合压缩前和压缩后评估标准.
- 配方F-7,使用Neusilin US2作为载体在40%的药物度,实现了98%的体外药物释放.
结论:
- 液态固体技术有效地提高了柳科的溶解率.
- 优化的配方 (F-7) 显示出显著的潜力,可以提高利科的生物可用性.
- 这项研究验证了液态固体技术作为制备水溶性较差的药物 (如利科) 的有希望的方法.
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