日本地幔细胞淋巴瘤患者的疾病管理景观:现实世界的研究
Shinya Rai1, Yoshinori Tanizawa2, Tomoko Terasawa2
1Department of Hematology and Rheumatology, Kindai University Hospital, Osakasayama, Japan.
Future oncology (London, England)
|September 8, 2025
概括
日本患有地幔细胞淋巴瘤 (MCL) 的患者表现出良好的疾病管理. 然而,为了获得最佳的患者结果,需要进一步改善治疗效果,安全性和生活质量.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 临床研究 临床研究
背景情况:
- 薄膜细胞淋巴瘤 (MCL) 是一种罕见的B细胞非霍奇金淋巴瘤.
- 了解日本当前的疾病管理环境对于改善患者护理至关重要.
研究的目的:
- 描述日本MCL患者目前的疾病管理策略.
- 评估治疗结果和医生在MCL管理中的感知目标.
主要方法:
- 进行了一项具有追溯数据收集的横截面调查.
- 医生调查了接受一线 (1L) 或复发/耐药 (R/R) 治疗的患者.
- 采集的数据包括患者人口统计,诊断,症状,治疗反应和副作用.
主要成果:
- 包括67名患者,主要是男性 (74.6%) 和经典的MCL (76.1%).
- 1L治疗的完整响应率为47.8%,第二线 (2L) 治疗为53.3%.
- 布鲁顿的氨酸激酶抑制剂 (BTKi) 与化疗相比副作用较少,医生的目标是尽量减少日常生活的影响或瘤反应.
结论:
- 在日本,MCL患者的治疗一般是很好的.
- 持续需要提高治疗疗效和安全性.
- 改善MCL患者的生活质量仍然是一个关键目标.
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