状细胞贫血与血管脉坏死有联系吗? 一个系统的审查
Elidiane Elias Ribeiro1,2, Karin Sá Fernandes3, Erika Sales Joviano Pereira4
1Department of Endodontics, School of Dentistry, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
概括
状细胞病 (SCD) 可能与完整的牙中的无血管脉死 (APN) 有关. 然而,由于研究的重大局限性和非常低的确定性,目前的证据是有限的.
科学领域:
- 口腔医学是指口腔医学.
- 血液学 血液学 血液学
- 遗传学 遗传学 是一个
背景情况:
- 状细胞病 (SCD) 是一种遗传性血红蛋白病.
- 血管脉坏死 (APN) 影响完整的牙.
研究的目的:
- 在完整的牙中系统地审查SCD和APN之间的关联.
- 评估有关这种关系的证据质量.
主要方法:
- 在8个数据库中进行全面搜索,截至2024年12月.
- 包括四项观察性研究 (队列和病例控制) 与311名患有状细胞贫血 (SCA) 的个人.
- 偏差风险和证据确定性使用JBI批判性评估检查清单和GRADE进行评估.
主要成果:
- 确定了SCA和APN之间的潜在关系.
- 所有纳入的研究都有高偏差风险 (≥30%).
- 证据的确定性被评为非常低.
结论:
- 对于APN和SCA之间的关联存在很弱的科学支持.
- 目前牙科文献中的方法限制阻碍了最终的结论.
- 需要进一步的高质量研究来澄清这种关系.
相关概念视频
Overview of the Vascular System
3.4K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
3.4K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
365
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
365
Peripheral Artery Disease IV: Nursing Management
351
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
351


