相对骨肌肉质量与代谢功能障碍相关的性肝病在社区人口中的发展之间的关联
Yiting Xu1,2, Tingting Hu1,2, Xiaoya Li1,2
1Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
保持足够的骨肌肉质量对于预防与代谢功能障碍相关的脂肪性肝病 (MASLD) 至关重要. 较高的相对肌肉质量与发展和持续MASLD的风险较低有关.
科学领域:
- 代谢健康 代谢健康
- 肝脏疾病研究 肝脏疾病研究
- 萨科佩尼亚和代谢综合征
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
- 骨肌肉质量与MASLD发育/缓解之间的关系需要在社区队伍中进一步调查.
研究的目的:
- 调查相对骨肌量与MASLD的发生率和缓解之间的关联.
- 探索骨肌肉质量与肝脏脂肪含量和纤维化之间的联系.
主要方法:
- 一个以社区为基础的1544名参与者的队列 (平均年龄58岁),具有基线和后续评估.
- 用生物电阻分析 (BIA) 测量骨肌肉质量;用体重和内脏脂肪面积 (VFA) 计算的相对质量.
- 通过超声波测定肝脂肪;使用NAFLD纤维化得分量化肝纤维化.
主要成果:
- 增加的相对总骨肌量 (调整为体重或VFA) 显著降低了男性和女性的MASLD发病率.
- 较高的相对尾骨肌肉质量也与降低的MASLD风险相关.
- 在相对的骨肌量和肝脏脂肪含量和纤维化之间观察到有统计学意义的反向关联.
结论:
- 相对较低的骨肌肉质量是MASLD发生率和持续性的危险因素.
- 增加骨肌肉质量的策略可能有利于MASLD的预防和管理.
更多相关视频
06:26Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
Published on: July 18, 2025
09:40Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
Published on: January 19, 2017
相关概念视频
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Disorders of the Skeletal Muscle
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
