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Updated: Jan 18, 2026

Detection of Nuclear Blebbing and DNA Leakage in Mammalian Cells by Immunofluorescence
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Cdk1依赖的层聚合是氧化应激诱导的核形状异常的基础

Ju-Hyun Ahn1, Min-Guk Cho2, Abdul Basit3

  • 1Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 16499; Department of Biomedical Sciences, The Graduate School of Ajou University, Suwon 16499, Korea; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, North Carolina 27599, USA.

BMB reports
|September 8, 2025
PubMed
概括

反应性氧物种 (ROS) 通过降低Cdk1活性来破坏线粒细胞中的核形态,导致层层聚合并影响核外重组. 这揭示了在细胞分裂过程中ROS诱导的核损伤的新机制.

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