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Updated: Jan 18, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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大脑的上调能通过线粒体功能重编程克服多发性骨髓瘤中thalidomide的抗性

Jubert Marquez1, Nammi Park2, Jae Hyeog Choi3

  • 1Basic Research Laboratory, Department of Physiology, College of Medicine, Smart Marine Therapeutic Center, Cardiovascular and Metabolic Disease Core Research Center, Inje University, Busan 47392, Korea; Department of Biology, De La Salle University, Manila 1004, Philippines.

BMB reports
|September 8, 2025
PubMed
概括

向大脑细胞 (CRBN) 可以通过重编程线粒体功能来克服多发性骨髓瘤中thalidomide的耐药性. 在耐药细胞中恢复CRBN水平可以增强细胞死亡,并在临床前模型中提高存活率.

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