慢性疼痛患者的睡眠质量,有或没有强烈的阿片类药物使用:使用可穿戴设备的观察性研究
Hiroko Ikemiya1, Keiko Yamada1,2, Satoko Chiba1
1Department of Anesthesiology and Pain Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.
Neuropsychopharmacology reports
|September 8, 2025
概括
慢性疼痛患者高剂量强度阿片类药物使用与睡眠不佳有关,包括更短的持续时间和更低的效率. 低剂量强度阿片类药物使用可能与更好的睡眠结果有关.
科学领域:
- 疼痛管理 疼痛管理
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿片类止痛药通常用于慢性疼痛,但它们对睡眠的影响仍然不完全理解.
- 这项研究调查了慢性非癌症疼痛患者不同程度的阿片类药物使用和睡眠特征之间的关系.
研究的目的:
- 为了比较慢性疼痛患者在不同类别的阿片类药物使用中的主观和客观的睡眠参数.
- 为了确定强阿片类药物对睡眠是否存在剂量依赖的影响.
主要方法:
- 29名慢性非癌症疼痛患者被分为非阿片类药物,弱阿片类药物和强阿片类药物使用者 (每天<60毫克和每天≥60毫克的吗啡相当剂量).
- 在七个晚上使用主观措施 (雅典失眠量表) 和客观措施 (总睡眠时间的可穿戴设备,入睡后的清醒[WASO]和睡眠效率) 来评估睡眠.
- 疼痛强度,心理因素 (灾难化,焦虑,抑郁,压力) 和人口统计数据被收集并用于统计调整.
主要成果:
- 与非阿片类药物使用者相比,使用强阿片类药物的患者每天≥60毫克的总睡眠时间显著缩短,WASO时间更长,睡眠效率较低,即使在调整混因素后.
- 那些每天使用60毫克以下的强阿片类药物的人表现出更短的WASO和更高的睡眠效率的趋势.
- 主观失眠症状在强度阿片类药物使用者中更为普遍,特别是在高剂量组中.
结论:
- 慢性疼痛患者高剂量强度阿片类药物消费与客观睡眠质量较差有关.
- 低剂量强度阿片类药物的使用可能不会对睡眠产生负面影响,并且可能与改善睡眠特征有关.
- 这些发现表明,在慢性疼痛管理中,强阿片类药物和睡眠障碍之间存在剂量依赖的关系.
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