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抑郁症状的代际连续性:遗传和环境途径
Marie C Navarro1, Marthe de Roo1, Albertine J Oldehinkel2,3
1Faculty of Behavioral and Social Sciences, Department of Pedagogy and Educational Sciences, https://ror.org/012p63287University of Groningen, Groningen, The Netherlands.
Psychological medicine
|September 8, 2025
概括
遗传和环境因素,包括父母的温暖,有助于抑郁症状的代际传播. 父母的抑郁会影响温暖,这反过来会影响后代.
科学领域:
- 精神病学和遗传学
- 发展心理学 发展心理学
- 行为科学 行为科学
背景情况:
- 由于遗传和环境因素的结合,抑郁症表现出家族性模式.
- 以前的研究经常单独研究遗传和环境对抑郁症的影响.
- 了解这些因素之间的相互作用对于解释代际连续性至关重要.
研究的目的:
- 检查遗传和环境影响对抑郁症状代际连续性的相互作用.
- 为了研究父母的抑郁症状和遗传倾向如何与后代的抑郁症状随着时间的推移有关.
- 评估父母的温暖作为这种传播中的环境调解者的作用.
主要方法:
- 利用了来自前性,基因知情的荷兰TRAILS队列 (n=2201) 的数据.
- 评估了两十年来父母的抑郁症状和后代的抑郁症状.
- 在统计模型中使用了抑郁症状的多基因分数和父母温暖度等级.
主要成果:
- 父母的抑郁症状,后代的遗传倾向和父母的温暖独立地预测了后代的抑郁症状.
- 在一个组合模型中,父母的遗传倾向影响了父母的抑郁症,这与父母的温暖程度较低有关.
- 随后,较低的父母温暖与后代抑郁症状的增加有关,独立于后代的遗传倾向.
结论:
- 遗传和环境因素在抑郁症状的代际传播中发挥着独立和相互作用的作用.
- 父母的温暖部分调解了父母抑郁症和后代抑郁症状之间的关系.
- 父母温暖的影响很小,这表明了复杂的相互作用和测量这种环境因素的潜在局限性.
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