在IMID患者中,扩大衰老的CD8T细胞与明显的炎症性细胞因子有关
Marie Naigeon1, Samuel Bitoun2, Matthieu Roulleaux Dugage1,3
1INSERM US23/CNRS UAR 3655, Laboratoire d'Immunomonitoring en Oncologie, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Clinical and experimental immunology
|September 8, 2025
概括
衰老的CD8T细胞 (T8sen) 在免疫媒介炎症疾病 (IMID) 中积累,这表明在这些疾病中免疫衰老是常见的. 抗TNF治疗没有影响RA和SPA患者的T8sen水平.
科学领域:
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
- 类风湿病学 类风湿病学
背景情况:
- 免疫衰老,以衰老的T细胞为特征,在慢性疾病中越来越多地被认可.
- 在免疫媒介性炎症性疾病 (IMIDs) 中T细胞衰老的作用仍然不完全理解.
研究的目的:
- 在风湿性关节炎 (RA) 和脊椎关节炎 (SpA) 患者中研究老化的T细胞 (T4sen和T8sen) 的比例.
- 评估抗TNF治疗对T细胞衰老的影响.
- 探索T细胞衰老,细胞因子和疾病特征之间的关联.
主要方法:
- 流细胞测量用于量化在RA,SPA,Sjögren综合征 (SjD),健康捐赠者和癌症患者中循环T4sen和T8sen的比例.
- 在基线测量了细胞因子水平 (IL-6,IP-10).
- 患者在基线和开始抗TNF治疗3个月后进行了评估.
主要成果:
- 与健康捐赠者和癌症患者相比,T8sen,但不是T4sen,在IMID患者中显著累积.
- 对CMV的阳性与T8sen积累的增加有关.
- 在SJD患者中,T8sen水平与SPA中的IL-6和SJD患者中的IP-10相关.
- 抗TNF治疗没有改变RA和SpA患者的T8sen比例,非响应者增加的趋势.
结论:
- 衰老的CD8T细胞在IMID患者中被丰富,表明免疫衰老是这些慢性炎症疾病的共同特征.
- T8sen与特定的炎症性细胞因子的关联表明,T8sen在IMIDs内塑造免疫反应中的作用.
关键词:
CD8 T 细胞 CD8 T 细胞斯约格伦氏病是斯约格伦氏病的一种疾病.这是一种抗TNF的药物.类风湿性关节炎 类风湿性关节炎衰老是一种老化.脊柱性关节炎 (spondyloarthritis) 是一种关节炎.更多相关视频
09:08Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
6.2K
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
725
相关概念视频
01:24T Cell Types and Functions
2.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.2K
01:22T Cell Activation and Clonal Selection
14.8K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
14.8K