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新生儿治疗前后肠道微生物群和代谢物的变化 患有高 bilirubinemia的新生儿
Liyi Mo1, Yanwen Luo1, Yan Liu2
1Department of Clinical Laboratory Medicine, The Fourth People's Hospital of Nanhai District of Foshan City, 528211 Foshan, Guangdong, China.
Frontiers in bioscience (Landmark edition)
|September 8, 2025
概括
新生儿黄的治疗显著改变了肠道细菌和代谢物,这表明肠道微生物组失调有助于改变胆红素代谢. 这突显了婴儿黄的潜在微生物组向治疗方法.
科学领域:
- 微生物学 微生物学
- 新生儿医学 新生儿医学
- 代谢学 代谢学 代谢学
背景情况:
- 新生儿黄影响高达60%的新生儿,病理病例与胆红素代谢受损和肠道微生物群失调有关.
- 肠道微生物群影响胆红素代谢的确切机制尚未完全理解.
- 这项研究调查了与治疗相关的肠道微生物群,便代谢物和新生儿肝功能变化.
研究的目的:
- 研究治疗对肠道微生物群组成,便代谢物和新生儿肝功能的影响.
- 探索肠道微生物群转移,代谢物变化和白代谢之间的关系.
- 确定新生儿黄的潜在治疗点和生物标志物.
主要方法:
- 分析了42名患有高白血症的新生儿,在治疗前和后收集了便样本.
- 用16S rRNA基因测序来评估肠道微生物组成,并通过非向代谢学来分析便代谢物.
- 测量肝功能参数,包括血清胆红素,并进行统计分析,包括多样性评估,相关性和KEGG通路丰富.
主要成果:
- 在治疗后,肠道微生物多样性下降,增加了*Streptococcus thermophilus*和*Rothia*,减少了*Pseudomonas*和*Staphylococcus*.
- 关键的变化代谢物包括9,11-甲-环氧PGF1α,前列腺素E2异烯酸和7-甲基乙烯基葡萄糖酸盐.
- 治疗后,总胆红素水平和其他肝功能标志物显著改善,在*S. thermophilus*丰度和某些代谢物之间观察到特定的相关性.
结论:
- 新生儿黄的治疗导致肠道微生物群和代谢物的显著变化,这表明微生物失调有助于改变胆红素代谢.
- 这些发现强调了针对微生物群的早期干预措施在治疗新生儿黄方面的潜力.
- 确定了新生儿黄的候选治疗标和生物标志物.
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