相关实验视频
Updated: May 9, 2026

06:55
Ileectomy-induced Bile Overaccumulation in Mouse Intestine
Published on: August 21, 2017
10.0K
病例报告:因自身免疫性胃炎引起的严重维生素B12缺乏症引起的可逆性胆病:一个全面的案例研究
Meifang Yang1,2,3, Yifan Geng1,2,3, Zhiren Chen3
1Department of Neurology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou School of Clinical Medicine of Nanjing Medical University, Xuzhou, Jiangsu, China.
Frontiers in nutrition
|September 8, 2025
概括
维生素B12缺乏会导致罕见的运动障碍,如胆症症状. 及时诊断和维生素B12替代疗法可以逆转这些症状,正如本案例研究所示.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 维生素B12缺乏会导致各种神经复杂症,包括认知障碍和神经病变.
- 超金字塔外运动障碍是维生素B12缺乏的罕见表现,往往导致诊断和治疗延迟.
- 脊髓的亚急性综合性退化是维生素B12缺乏的一个众所周知的神经系统后果.
研究的目的:
- 为了呈现一种急性发病的choreoathetoid症状二次的维生素B12缺乏.
- 突出18F-FDG PET/CT在识别与维生素B12缺乏相关的基底高代谢中的诊断效用.
- 强调早期诊断和治疗维生素B12缺乏对神经恢复的重要性.
主要方法:
- 一个66岁的男性病人的病例报告呈现出急性胆固醇症状.
- 诊断工作包括神经检查,维生素B12水平的生物化学测试和18F-FDG PET/CT.
- 对维生素B12缺乏症的病因调查,包括对吸收不良和饮食摄入量的评估.
主要成果:
- 患者在18F-FDG PET/CT上表现出严重的维生素B12缺乏和基底质中的异常高代谢.
- 在维生素B12替代疗法后,胆症的症状完全消失.
- 基本原因被确定为维生素B12吸收不良和由于自身免疫性胃炎而导致的饮食摄入不足的组合.
结论:
- 维生素B12缺乏症可能会出现罕见的超金字塔运动障碍,如果及时治疗,这些障碍是可逆的.
- 18F-FDG PET/CT可以帮助诊断维生素B12缺乏症的神经影响.
- 全面的病因调查和及时的治疗对于维生素B12缺乏症和神经症状患者的最佳结果至关重要.
相关概念视频
Myasthenia Gravis: Overview and Treatment
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Vitamins
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Gastritis-II: Pathophysiology
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Gastritis II: Pathophysiology
The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

