通过生活方式表观遗传调节:饮食,运动和正念的进步,用于疾病预防和健康优化
José Ostaiza-Cardenas1, Andrea C Tobar2, Stefany Carolina Costa2
1School of Medicine, Medical Sciences Faculty, Universidad de Guayaquil, Guayaquil, Ecuador.
Frontiers in nutrition
|September 8, 2025
概括
现代生活方式的选择,如饮食,运动和正念,通过影响表观遗传变化,可以对健康产生积极影响. 这些做法促进基因表达,有助于预防疾病和整体福祉.
科学领域:
- 表观遗传学与健康
- 生活方式 医学 医疗
- 预防医学 预防医学
背景情况:
- 社会经济和环境因素通过表观遗传修饰影响健康.
- 生活方式的选择是表观遗传机制和疾病风险的关键调节者.
研究的目的:
- 系统地审查生活方式干预及其对表观遗传结果和健康的影响.
- 评估饮食,运动和正念在调节基因表达和预防疾病中的作用.
主要方法:
- 在过去的13年里,在遵守PRISMA指南的基础上进行了系统审查.
- 对干预措施,表观遗传标记 (如DNA甲基化) 和健康影响的研究分析.
- 包括各种生活方式因素:饮食,体育活动和正念.
主要成果:
- 正念实践,特别是冥想,调节DNA甲基化,减少压力和炎症.
- 饮食干预措施 (地中海,DASH饮食) 改善生物标志物和减缓表观遗传衰老.
- 身体活动诱导表观遗传修饰,增强代谢功能和胰岛素敏感性.
结论:
- 采用现代生活方式选择对促进健康和预防疾病的基因表达产生积极影响.
- 结合正念,均衡饮食和炼,提供了显著的代谢,心血管和心理健康益处.
- 对长期表观遗传效应和个性化预防策略需要进一步研究.
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