在沙特患者中,患有甲胺和大麻使用障碍的认知功能
Shrief Y Afifi1,2, Abdulkhaliq S S Alghamdi2, Ahmed Sallam2
1Neuropsychiatry Department, Okasha Institute of Psychiatry, Ain Shams University, Cairo, Egypt.
Frontiers in psychiatry
|September 8, 2025
概括
甲基胺和大麻使用障碍严重损害了沙特患者的认知功能. 与大麻使用障碍相比,甲基胺使用障碍显示出更严重的认知缺陷.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成 药物 药物 药物 药物
背景情况:
- 甲基胺使用障碍 (MUD) 和大麻使用障碍与认知和神经精神疾病缺陷有关.
- 之前的研究表明,这两种物质的使用者都有显著的认知障碍,尽管一些发现仍在争论中.
- 这项研究调查了沙特人口中MUD和大麻使用障碍的认知影响.
研究的目的:
- 评估和比较沙特患者中甲基胺使用障碍和大麻使用障碍的认知影响.
- 确定受这些物质使用障碍影响的特定认知领域.
- 建立一个基线,以了解这个人口群体中神经心理的影响.
主要方法:
- 对三组进行了横截面观察性研究:MUD患者,大麻使用障碍患者和健康的对照组.
- 参与者接受了最近使用毒品的尿液毒理测试和SCID-I访谈,以确认诊断并排除其他精神疾病.
- 用蒙特利尔认知评估 (MoCA),韦克斯勒记忆量表和Stroop执行功能测试来评估认知功能.
主要成果:
- 在所有测试的认知领域中,在物质使用障碍患者和对照组之间观察到认知功能的显著差异.
- 与对照组相比,患有MUD或大麻使用障碍的患者在大多数认知特征上呈现出统计学上显著的损伤.
- 甲基胺使用障碍患者表现出比大麻使用障碍患者更明显的认知缺陷.
结论:
- 甲基胺和大麻使用障碍都会对沙特研究人口的认知功能产生负面影响.
- 与大麻使用障碍相比,甲基胺使用障碍似乎对认知能力有更严重的影响.
- 这些发现凸显了沙特阿拉伯与这些物质使用障碍相关的大量认知负担.
相关概念视频
01:24CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
792
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
792
01:24Substance Use Disorders Affecting Sleep
403
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
403
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
563
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
563
01:15Drug Abuse and Addiction: Pharmacological Phenomena
1.1K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.1K
01:29Stimulants
848
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
848
01:28An Overview of Psychoactive Drugs
585
Psychoactive drugs impact brain function, influencing perception, mood, consciousness, cognition, and behavior. These substances are grouped based on their effects and the mechanisms by which they act.
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
585